Created: 2020-09-16 Wed 13:28
| Frank Jülicher | The Barnes/Drubin Lab | Tyler Harmon |
Hypothesis: CME proteins can undergo LLPS
| Trigger actin assembly | Mechanical work |
| [li_phase_2012] | [lacy_molecular_2018] |
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-C_{i}\right)^{2}+\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}+P V_{i}\)
| Side view | Top view |
membrane tension
\(\sigma\left(S_{0}+S_{m}+S_{i}\right)\)
bending energy
\(\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-C_{i}\right)^{2}\)
combined membrane tension and bending energy
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-C_{i}\right)^{2}\)
surface tension
\(\gamma_{d} S_{d}\)
wetting energy (note: negative contribution!)
\(\gamma_{m} S_{m}+\gamma_{i} S_{i}\)
combined surface tension and wetting energy
\(F=\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}\)
\(P V_{i}\)
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-C_{i}\right)^{2}+\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}+P V_{i}\)
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-C_{i}\right)^{2}+\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}+P V_{i}\)